In vivo Electrophysiology

Muriphys leverages advanced in vivo electrophysiology to capture how pharmaceutical compounds influence neuronal firing patterns and overall network connectivity within the brain. This high-resolution perspective enables the precise identification of drug targets, a deeper understanding of therapeutic mechanisms, and a clearer view of potential side effects. By integrating drug delivery expertise, cutting-edge electrophysiological assessments, and behavioral evaluations, Muriphys provides sponsors with a multifaceted framework that drives informed decision-making at every step of preclinical development, ultimately smoothing the path toward successful clinical translation.

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Comprehensive Neurological Assessments

• Muriphys applies EEG to track real-time brain activity, allowing researchers to capture subtle neuronal firing shifts and network connectivity changes.
• With EMG techniques, the team monitors muscle activation patterns and neuromuscular junction integrity, generating insights into motor function, disease progression, and therapeutic efficacy.
• ERG measures retinal response to various stimuli, enabling early detection of ocular toxicity or confirmation of target engagement in sight-related disorders.

Cutting-Edge Technology & Methods

• Advanced data acquisition systems capture high-fidelity signals, minimizing noise and improving reproducibility.
• Proprietary protocols and validated SOPs help streamline the setup and execution of EEG, EMG, and ERG procedures.
• Robust quality control measures ensure data integrity, allowing sponsors to rely on consistent, accurate findings.

Integrated Study Design

• Muriphys expertly combines drug delivery with EEG/EMG/ERG measurements to provide a holistic view of compound safety and efficacy.
• Tailored study designs meet sponsor objectives—whether early proof-of-concept screening or more advanced regulatory requirements.
• This end-to-end integration significantly shortens development timelines by eliminating the need for multiple external vendors.

Expertise in Diverse Therapeutic Areas

• Decades of combined experience allow Muriphys to adapt its electrophysiology platform to a wide array of indications, from CNS disorders and neuromuscular diseases to ophthalmic conditions.

• Cross-functional teams with backgrounds in pharmacology, neuroscience, and bioengineering collaborate to interpret results within each sponsor’s specific therapeutic context.

Partner-Centric Approach

• Each project receives dedicated support from a specialized team that remains accessible throughout the study, maintaining open channels of communication.
• Sponsors benefit from thorough data analyses, interpretive reports, and strategic recommendations that drive informed go/no-go decisions.
• Customized timelines, resource allocation, and study endpoints accommodate both large and small biotech entities, reflecting Muriphys’s commitment to client success.

By offering a synergistic blend of EEG, EMG, and ERG expertise—backed by robust drug delivery and preclinical development capabilities—Muriphys stands out as a premier partner, facilitating faster, more reliable data to guide discovery and translational efforts.