Eye Diseases

Eye diseases, often progressive and debilitating, require cutting-edge research tools to drive the development of effective treatments. At Muriphys, we specialize in preclinical models that mimic the complexities of ocular conditions, offering advanced drug delivery methods and in-depth behavioral and imaging assessments. Our expertise spans genetic, degenerative, and pressure-related eye disorders, ensuring comprehensive support for groundbreaking therapies.

Muriphys’ state-of-the-art platforms provide unparalleled insights into retinal degeneration, corneal dystrophies, and optic nerve damage, helping you transform innovative ideas into transformative treatments.

Eye Diseases We Specialize In:

Retinitis Pigmentosa (RP)
Retinitis Pigmentosa, a genetic disorder causing progressive photoreceptor degeneration, demands precise intervention at the retinal level. Muriphys employs adeno-associated virus (AAV) vectors for gene therapy delivery, alongside intravitreal (IVT) injections to achieve localized drug distribution. Our optodrum and OCT imaging tools track visual function and retinal integrity, providing comprehensive endpoints for therapeutic development.

Glaucoma
Characterized by optic nerve damage and elevated intraocular pressure, glaucoma research benefits from Muriphys’ targeted delivery systems. Intravitreal and intracameral (IC) injections ensure precise drug administration, while behavioral assays and OCT imaging monitor pressure regulation and optic nerve health. Our preclinical models simulate both open-angle and angle-closure glaucoma, offering robust testing environments for novel therapeutics.

Fuchs Endothelial Corneal Dystrophy (FECD)
FECD, driven by corneal endothelial cell degeneration, presents unique challenges in therapy development. Muriphys utilizes intracameral injections and topical drug delivery to target the corneal endothelium directly. Imaging technologies, including OCT, track corneal clarity and thickness, while ERG and optodrum tests assess visual function, providing a complete picture of disease progression and therapeutic efficacy. Read More.

Why Muriphys for Eye Disease Research?

• Precision Ocular Delivery: From intravitreal to intracameral injections, our delivery systems enable targeted administration, ensuring maximal therapeutic impact while minimizing off-target effects.
• Advanced Imaging and Functional Testing: OCT, ERG, and optodrum technologies provide non-invasive insights into retinal health, corneal structure, and overall visual function, enhancing data quality and reliability.
• Comprehensive Disease Modeling: Our preclinical models replicate the full spectrum of ocular diseases, supporting gene therapies, biologics, and small molecule interventions with unparalleled accuracy.
• Customized Study Designs: Muriphys tailors every study to reflect the unique pathophysiology of each eye disease, ensuring your research achieves the depth and specificity required for successful translation to the clinic.

At Muriphys, we bring vision to life through innovative research, equipping scientists with the tools to pioneer the next generation of ocular therapeutics.

Illuminate the path to ocular health with Muriphys—where precision and innovation redefine possibilities in eye disease research.