LC-HRMS Bioanalysis & PK

At Muriphys, our LC-HRMS platform offers high-sensitivity, high-throughput bioanalytical support for nonclinical and early-stage clinical studies. We specialize in the quantitative analysis of small molecules, biologics, and their metabolites across a wide array of biological matrices. Our services are fully customizable, built to support IND-enabling programs, proof-of-concept studies, and exploratory pharmacokinetic assessments.

Our Capabilities Include:

  • Method Development & Validation
    Custom LC-HRMS method development for complex small molecules and bioactive compounds. We follow FDA and EMA guidance for non-GLP and GLP-compliant validation when needed.
  • Quantitative Bioanalysis
    Accurate quantification of analytes in plasma, serum, CSF, tissue homogenates, urine, and other matrices. Our workflows support sample sets from early discovery to formal toxicokinetic studies.
  • Pharmacokinetics (PK) & Toxicokinetics (TK)
    Full PK/TK support, including study design, sample collection, time-point analysis, and non-compartmental modeling. Our scientists work closely with clients to generate actionable data for dosing strategy and safety assessment.
  • Metabolite Identification & Profiling
    Using high-resolution mass spectrometry, we identify major metabolites and provide metabolic stability and pathway characterization, informing structure-activity relationships and downstream DMPK strategy.
  • Tissue Distribution & Biodistribution Studies
    Quantitative detection of parent drug and metabolites in CNS and peripheral tissues via validated qPCR or LC/MS protocols, including post-AAV administration biodistribution support.
  • Immunogenicity & Drug-Target Quantification
    Integration of LC/MS with immunoaffinity enrichment for protein therapeutics and anti-drug antibody detection.

Instrumentation

  • Triple quadrupole LC-HRMS systems (Waters, SCIEX, Thermo)
  • UPLC systems for high-resolution separations
  • High-resolution QTOF for metabolite ID and biomarker discovery
  • Automated sample preparation platforms to support high-throughput workflows

Why Choose Muriphys?

  • Rapid turnaround with expert-level project guidance
  • Direct access to scientific staff for method strategy and interpretation
  • Seamless integration with in vivo pharmacology and tissue collection
  • Optional pre-analytical consultation to optimize sampling schedules and stability conditions
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