Start-to End Preclinical Neurobiology Service

We aim to be your trusted partner in advancing solutions for neurodegenerative and neurodevelopmental diseases. Our extensive preclinical experience enables us to select the most suitable animal models, administer a diverse range of drug candidates, and employ assays that effectively validate your hypothesis in vivo.

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From the initial stages of collaboration, our approach provides the resources necessary to propel your novel therapies toward meaningful advancements in human health. Our role is to de-risk and simplify your research, helping you reach breakthrough results efficiently.

We specialize in neurodegenerative and neurodevelopmental disorders such as Huntington’s Disease, Ataxia, and Rett Syndrome, and have deep knowledge in rodent models of these diseases including (not limited to) the following 6 mouse models:

  • Tg/Tg
  • Atxn1−/−
  • BACHD
  • YAC128
  • FXNYG8Pook/800J
  • B6.129P2(C)-Mecp2tm1.1Bird/J

With our expertise, we can successfully deliver various classes of drug candidates and their associated delivery vehicles:

Drug Candidate Classes:

  • DNA
  • RNA
  • Protein
  • Small molecules

Delivery Vehicles:

  • AAV (Adeno-Associated Virus)
  • Lentivirus
  • LNP (Lipid Nanoparticles)

Delivery Routes:

  • Intraparenchymal
  • Intracerebroventricular
  • Cisterna Magna
  • Intrathecal
  • Canula implants
  • Osmotic pumps implants

Our cutting-edge surgical robotics ensure precise drug delivery with 1 µm accuracy, targeting specific brain structures while minimizing variability.

Neurobiology Assays and Behavioral Studies

    Additionally, we provide comprehensive behavioral assays to assess neurological function, including:

    • Rotarod
    • Noldus Catwalk
    • Analysis with Treadmill
    • Forced Treadmill
    • Grip Strength
    • Shuttle Box
    • O Maze
    • Social Behavior
    • Plantar Test

    With our deep expertise in preclinical drug development, we can guide you through model selection, drug delivery, and the validation of your therapeutic hypothesis. Together, we can accelerate the path to groundbreaking discoveries.

    Download our CNS delivery white paper

    Download our preclinical development white paper

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