Neurodevelopmental Disorders

Neurodevelopmental disorders shape the lives of millions, affecting cognitive, social, and motor functions from an early age. At Muriphys, we are dedicated to providing innovative preclinical solutions that drive the development of therapies for these complex conditions. Our models mirror the genetic and environmental factors underlying neurodevelopmental disorders, offering precision drug delivery and comprehensive behavioral assessments.

Muriphys partners with researchers to accelerate breakthroughs, shedding light on conditions such as autism, Fragile X syndrome, and Rett syndrome. Together, we shape the future of therapeutic intervention for those affected by developmental challenges.

Disorders We Specialize In:

Autism Spectrum Disorder (ASD)
Autism Spectrum Disorder is characterized by challenges in social interaction, communication, and repetitive behaviors. Muriphys offers preclinical models utilizing intraparenchymal (IPa), intracerebroventricular (ICV), and intrathecal (IT) delivery to target key brain regions involved in ASD. Our behavioral assays assess social engagement, sensory processing, and motor coordination, while EEG studies provide biomarkers for neural dysfunction, guiding precision treatment development.

Fragile X Syndrome
Fragile X, a leading genetic cause of intellectual disability and autism, demands specialized models to capture its broad cognitive and behavioral effects. Muriphys leverages CNS and systemic drug delivery methods, including viral vectors and ICV administration, to ensure accurate targeting. Our comprehensive suite of behavioral assays evaluates learning, attention, and sensory responses, while electrophysiology identifies neural hyperexcitability, a hallmark of Fragile X pathology.

Rett Syndrome
Rett Syndrome primarily affects girls, leading to severe impairments in motor function, communication, and cognition. Muriphys’ targeted delivery methods, including IPa and IT routes, facilitate drug distribution to cortical and spinal regions. Behavioral assessments track motor deficits and hand movements, while EEG and EMG recordings monitor seizure activity and neurological decline, offering critical endpoints for therapeutic evaluation. Read More.

Tourette Syndrome
Tourette Syndrome’s involuntary motor and vocal tics require specialized models that reflect its neurological basis. Muriphys delivers therapeutics using IPa and ICV methods, targeting motor circuits and limbic pathways. Behavioral assays capture tic frequency and severity, while EEG recordings provide insights into the underlying neural activity, ensuring robust evaluation of potential treatments.

Why Muriphys for Neurodevelopmental Research?

  • Targeted Drug Delivery Systems: Our advanced CNS delivery methods ensure precise administration to developing brain regions, maximizing therapeutic potential.
  • Comprehensive Behavioral Testing: From social interaction to motor coordination, our assays provide detailed insights into the full spectrum of neurodevelopmental symptoms.
  • Electrophysiological Expertise: EEG and EMG recordings track neural development and seizure activity, offering critical biomarkers for early intervention studies.
  • Tailored Research Models: Muriphys designs customized studies that reflect the unique developmental trajectories of each disorder, ensuring translational relevance and impactful results.

Muriphys stands at the forefront of neurodevelopmental disorder research, providing the tools and expertise necessary to advance new therapies and improve outcomes for affected individuals.

Shape the future of neurodevelopmental research with Muriphys—where innovation meets discovery, and precision unlocks potential.

Back to previous

SPEAK TO A SCIENTIST