Neurodegenerative disorders
At MuriPhys, we are not just a preclinical CRO—we are your partner in the relentless pursuit of breakthroughs in neurodegenerative disease therapeutics. Our comprehensive suite of services bridges the gap between discovery and clinical translation, empowering your research with unparalleled precision and depth.
Neurodegenerative diseases represent some of the most complex medical challenges of our time. Our advanced behavioral modalities and delivery systems provide a robust platform for studying the pathology, progression, and potential treatments of these debilitating conditions. From Huntington’s and Parkinson’s to ALS and Ataxia, Muriphys offers tailored solutions designed to illuminate every facet of disease progression and intervention.
Diseases We Specialize In:
Huntington’s Disease
MuriPhys provides specialized tools to investigate the progressive neuronal degeneration characteristic of Huntington’s. Our intraparenchymal (IPa) drug delivery directly targets the striatum and cortex—key regions affected by the disease. Complementing this, we offer behavioral assessments such as rotarod, balance beam, and Y-maze, alongside electrophysiological studies (EEG, EMG) to track disease markers and therapeutic efficacy at every stage. Read More.
Ataxia
Ataxia research benefits from MuriPhys’ targeted delivery to the cerebellar cortex and deep nuclei. Our array of behavioral tests assesses gait, balance, and motor coordination, while electrophysiological recordings track cerebellar activity and disease evolution. Read More.
Parkinson’s Disease
Parkinson’s research demands precision and versatility. Our intraparenchymal (IPa) delivery into the substantia nigra, as well as intracerebroventricular (ICV) and intrathecal (IT) options, ensure targeted and systemic drug distribution. Behavioral assays replicate hallmark symptoms, while EEG and EMG studies provide insight into motor and neuromuscular changes over time. Read More.
Amyotrophic Lateral Sclerosis (ALS)
ALS devastates motor neurons, and MuriPhys addresses this with IPa and ICV delivery focused on the motor cortex and spinal cord. Our assays, including open field and OCT imaging, capture the progression of muscle atrophy and coordination deficits, enabling the rigorous evaluation of novel therapeutics. Read More.
Dementias
From Alzheimer’s to Lewy Body and Frontotemporal Dementia, MuriPhys provides comprehensive tools to dissect the complexities of cognitive decline. Our drug delivery platforms span intraparenchymal, ICV, and IT routes, facilitating localized and systemic targeting. Behavioral assays explore memory and learning, while EEG recordings highlight neuronal dysfunction, offering crucial biomarkers for early detection and progression tracking.
Why MuriPhys?
- Precision Delivery Systems: Our cutting-edge intraparenchymal, intracerebroventricular, and intrathecal delivery options are meticulously designed to ensure accuracy and reproducibility.
- Comprehensive Behavioral Assays: From cognitive tests to motor coordination challenges, we simulate disease phenotypes with unparalleled accuracy.
- Advanced Electrophysiology: EEG and EMG recordings provide a window into disease progression and therapeutic impact, ensuring your studies capture every detail.
- Tailored Solutions: We customize our services to align with the unique demands of your research, offering scalable, adaptable models that reflect the intricacies of each neurodegenerative condition.
At MuriPhys, we transform complex research questions into actionable insights, accelerating the path to groundbreaking therapies. Partner with us—where science meets precision, and innovation drives discovery.
Explore our full suite of neurodegenerative models and services. Together, we shape the future of neurological therapeutics.
