Pain Disorders

Chronic and acute pain disorders affect millions worldwide, often diminishing quality of life and posing significant treatment challenges. At Muriphys, we specialize in preclinical models that unravel the complexities of pain pathways, providing critical insights into novel therapeutics. Our advanced drug delivery platforms and behavioral assays enable the precise evaluation of pain responses, ensuring comprehensive data for the development of cutting-edge pain management solutions.

Muriphys partners with researchers to explore breakthrough therapies that target the neurological and physiological roots of pain, driving innovation toward long-lasting relief.

Pain Disorders We Specialize In:

Neuropathic Pain
Neuropathic pain, arising from nerve damage, requires targeted interventions that address both peripheral and central sensitization. Muriphys offers intraparenchymal (IPa), intracerebroventricular (ICV), and intrathecal (IT) drug delivery methods to ensure precise administration to affected regions. Behavioral assays such as the plantar test and conditioned place preference model assess pain sensitivity, while electrophysiological recordings provide insights into neural hyperexcitability. Read More.

Inflammatory Pain
Inflammatory pain results from tissue damage and immune response activation. Muriphys utilizes systemic and CNS delivery approaches to evaluate anti-inflammatory compounds, with oral gavage (OG), intraperitoneal (IP), and subcutaneous (SC) delivery options. Behavioral models, including open field and rotarod tests, track pain-induced changes in mobility and behavior, ensuring comprehensive assessment of therapeutic efficacy. Read More.

Visceral Pain
Visceral pain, often associated with internal organ dysfunction, presents unique challenges for therapeutic intervention. Muriphys employs IPa and ICV drug delivery to target central pain processing centers, while behavioral assays monitor abdominal writhing and referred pain responses. Electrophysiological studies further elucidate pain signal transmission and modulation, supporting the development of targeted analgesics. Read More.

Why Muriphys for Pain Research?

  • Targeted Drug Delivery Systems: Our advanced CNS and systemic delivery platforms ensure precise therapeutic administration, enhancing data accuracy and reproducibility.
  • Comprehensive Behavioral Assays: From thermal pain sensitivity to complex conditioned responses, our behavioral tests capture the full spectrum of pain phenotypes, providing actionable insights for therapeutic development.
  • Electrophysiology for Deeper Understanding: EEG and EMG recordings reveal the neural mechanisms underlying pain, enabling the identification of biomarkers and tracking treatment responses.
  • Tailored Models for Translational Research: Muriphys specializes in pain models that reflect the multifaceted nature of pain disorders, ensuring that therapeutic evaluations align with clinical realities.

Muriphys leads the way in pain disorder research, offering the expertise and technology necessary to develop the next generation of pain management therapies.

Partner with Muriphys to drive innovation in pain research—where precision and discovery pave the way to relief.

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