Visceral Pain Solutions

Visceral pain, originating from internal organs, represents one of the most challenging forms of chronic pain to diagnose and treat. At Muriphys, we specialize in preclinical models that replicate the intricate mechanisms driving visceral pain, offering comprehensive insights to accelerate the development of targeted therapies.

Our advanced drug delivery systems, behavioral assays, and electrophysiological tools provide a full-spectrum approach to studying visceral pain, empowering researchers to uncover novel therapeutic interventions that address both peripheral and central components of this debilitating condition.

Visceral Pain Research Focus Areas:

Gastrointestinal (GI) Pain
GI pain conditions such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) require nuanced models to capture both peripheral and central sensitization. Muriphys utilizes intraparenchymal (IPa), intrathecal (IT), and systemic delivery methods to target gut-brain pathways. Behavioral assays, including writhing tests, gastric emptying, and motility studies, assess pain responses, while electrophysiology tracks neural activity in visceral afferents and spinal circuits.

Urological and Pelvic Pain
Conditions like interstitial cystitis and chronic pelvic pain demand precision in drug delivery to pelvic and spinal regions. Muriphys employs intracerebroventricular (ICV) and IPa delivery to administer therapeutics directly to regions regulating pelvic pain. Behavioral assays such as referred hyperalgesia and bladder distension models assess pain intensity, while EEG and EMG provide insights into autonomic nervous system dysregulation.

Cardiothoracic and Abdominal Pain
Cardiac, thoracic, and abdominal pain often results from organ ischemia or inflammation. Muriphys utilizes systemic (IV, IP) and localized (IPa, ICV) delivery methods to target pain processing centers. Behavioral models such as post-surgical pain assessments and diaphragm stimulation track nociceptive responses, while electrophysiological recordings capture pain signal transmission along spinal and vagal pathways.

Why Muriphys for Visceral Pain Research?

  • Targeted Drug Delivery: Our intrathecal, intracerebroventricular, and systemic platforms enable precise drug administration to visceral pain pathways, ensuring accurate and reproducible results.
  • Comprehensive Pain Modeling: Muriphys’ behavioral assays capture both spontaneous and evoked visceral pain responses, delivering robust endpoints for therapeutic evaluation.
  • Electrophysiological Insights: EEG, EMG, and visceral nerve recordings provide critical data on neural plasticity, sensitization, and pain transmission, illuminating new pathways for intervention.
  • Customized Preclinical Models: Muriphys designs tailored studies that reflect the unique characteristics of visceral pain disorders, ensuring translational relevance and alignment with clinical outcomes.

Muriphys leads visceral pain research with unparalleled expertise, helping scientists unlock new therapeutic avenues and improve patient outcomes.

Reach out now to discover how our innovative approach can help your organization get the results you need in your research faster, and in more detail.

Transform visceral pain research with Muriphys—where innovation meets precision and discovery drives relief.

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