Inflammatory Pain
Understanding Inflammatory Pain
Inflammatory pain arises from tissue damage and subsequent immune response, resulting in heightened sensitivity, swelling, and persistent discomfort. This type of pain is commonly associated with conditions such as arthritis, injury, and autoimmune disorders. The study of inflammatory pain is crucial for developing analgesics and anti-inflammatory therapies that improve patients' quality of life.
At Muriphys, we specialize in providing advanced preclinical research solutions to investigate the mechanisms of inflammatory pain and evaluate potential therapeutic interventions.
Targeted Drug Delivery for Pain Models
Effective pain management often relies on precise delivery of therapeutic agents to inflamed tissues or directly to the nervous system. Muriphys offers a diverse array of drug delivery methods tailored to inflammatory pain models:
- Intraparenchymal (IPa) Delivery – Direct administration to specific CNS regions involved in pain processing.
- Intrathecal (IT) Injection – Delivery to the spinal cord to block pain transmission at the central level.
- Intraperitoneal (IP) Injection – Systemic delivery to address peripheral inflammation and pain.
- Oral Gavage (OG) – Mimics human oral drug administration, ensuring translational relevance.
- Subcutaneous (SC) and Intravenous (IV) Injections – Enable systemic or localized drug distribution.
These delivery methods ensure optimal dosing and effective targeting of inflammatory pathways, enhancing therapeutic outcomes.
Behavioral Assays for Pain Evaluation
Behavioral assays are essential for quantifying pain sensitivity and evaluating the effectiveness of analgesics. Muriphys provides a comprehensive suite of assays designed to model inflammatory pain and assess therapeutic impact:
- Plantar Test (Hargreaves Method) – Measures thermal hyperalgesia in response to noxious heat stimuli.
- Von Frey Filament Testing – Evaluates mechanical allodynia by measuring withdrawal responses to light touch.
- Open Field Test – Assesses movement and pain-induced postural changes.
- Rotarod and Balance Beam Tests – Evaluate motor coordination, impaired by inflammation and pain.
- Conditioned Place Preference (CPP) – Explores the analgesic effect of treatments through associative learning models.
These assays provide critical insights into pain perception, mobility, and behavior, facilitating the development of novel pain relief strategies.
Electrophysiology – Unraveling Pain Pathways
Understanding the neural correlates of pain is pivotal to developing targeted therapies. Muriphys leverages EEG and EMG technologies to assess the electrical activity of pain-processing circuits and muscle responses, providing valuable data on the effectiveness of analgesic compounds.
Electrophysiological services include:
- EEG Recording – Monitors cortical activity to detect neural signatures associated with pain perception.
- EMG Analysis – Measures muscle reflex responses and neuromuscular involvement in pain conditions.
These advanced tools help map the neural pathways involved in pain and track how interventions modulate pain signals.
Why Choose Muriphys for Inflammatory Pain Research?
Muriphys is a trusted partner in preclinical inflammatory pain research, offering comprehensive solutions that integrate precision drug delivery, validated pain assays, and cutting-edge electrophysiology. Our tailored approach ensures accurate modeling of inflammatory pain, accelerating the path to breakthrough therapeutics.
Let Muriphys drive your inflammatory pain research forward, transforming discoveries into effective treatments.
Contact us to explore our capabilities in pain research.
