Neuropathic Pain Solutions
Neuropathic pain is a complex, debilitating condition arising from nerve damage or dysfunction. It affects millions globally, often resisting conventional treatments. At Muriphys, we specialize in advanced preclinical models that dissect the underlying mechanisms of neuropathic pain, paving the way for innovative and effective therapeutics.
Our state-of-the-art platforms integrate precision drug delivery, comprehensive behavioral assessments, and electrophysiological analysis, providing a robust foundation for the development of next-generation pain management solutions.
Neuropathic Pain Research Focus Areas:
Peripheral Neuropathic Pain
Peripheral nerve injury often leads to chronic pain syndromes. Muriphys utilizes intraparenchymal (IPa), intrathecal (IT), and intravenous (IV) delivery systems to administer therapeutics directly to the spinal cord and peripheral nerves. Behavioral assays, including the plantar test, von Frey test, and dynamic weight-bearing analysis, monitor hypersensitivity and mechanical allodynia, while electrophysiology tracks neural excitability and pain signal transmission.
Central Neuropathic Pain
Damage to the central nervous system (CNS) from conditions such as stroke or spinal cord injury often results in central neuropathic pain. Muriphys leverages intracerebroventricular (ICV) and intraparenchymal drug delivery to target affected brain and spinal regions. Behavioral tests assess thermal hyperalgesia and spontaneous pain responses, while EEG and EMG recordings provide critical insights into CNS plasticity and maladaptive pain circuits.
Chemotherapy-Induced Neuropathy
Chemotherapy agents frequently cause nerve damage, leading to long-term pain and sensory deficits. Muriphys employs systemic and CNS-targeted delivery methods to evaluate neuroprotective compounds. Behavioral assays such as gait analysis and cold plate tests capture the impact of chemotherapy on nerve function, while electrophysiology measures alterations in nerve conduction and synaptic integrity.
Why Muriphys for Neuropathic Pain Research?
- Targeted Delivery Systems: Our IPa, IT, and ICV platforms ensure precision drug administration to the spinal cord, brain, and peripheral nerves, enhancing therapeutic accuracy.
- Comprehensive Pain Modeling: Muriphys’ behavioral assays capture the full range of neuropathic pain symptoms, from mechanical allodynia to thermal hyperalgesia, providing detailed endpoints for drug development.
- Electrophysiological Expertise: EEG, EMG, and nerve conduction studies reveal critical biomarkers for neuropathic pain, offering valuable insights into disease mechanisms and therapeutic efficacy.
- Customized Research Programs: Muriphys designs tailored neuropathic pain models that reflect the pathophysiology of diverse pain conditions, ensuring translational relevance and clinical impact.
Muriphys stands at the forefront of neuropathic pain research, equipping scientists with the tools and expertise necessary to develop transformative therapies.
Contact us today to learn how our expertise can help your organization excel.
Advance neuropathic pain research with Muriphys—where precision science meets groundbreaking discovery.
