Genetically engineered mouse models
Genetically engineered mouse models (GEMMs) are invaluable in preclinical oncology research for their ability to faithfully recapitulate the genetic and molecular landscape of human cancers. These models enable the spontaneous development of tumors within their native microenvironment, allowing for the study of tumor initiation, progression, metastasis, and immune system interactions in a physiologically relevant context. GEMMs are particularly powerful for evaluating targeted therapies, resistance mechanisms, and gene-specific treatment responses. At MuriPhys, we are well equipped to support studies using GEMMs through our expertise in transgenic colony management, in vivo imaging, and advanced behavioral and physiological monitoring. Our team’s experience with complex breeding strategies and surgical techniques ensures precise execution of studies involving tumor-prone models, making MuriPhys a strong partner for advancing innovative cancer therapies through genetically defined systems.
SPEAK TO A SCIENTIST
Below is a list of available models commonly used by MuriPhys researchers:
- Mice engineered to develop spontaneous tumors that metastasize naturally.
- Oncogene activation (e.g., KRAS, MYC) or tumor suppressor loss (e.g., p53, PTEN) triggers metastasis.
- Examples:
- MMTV-PyMT (breast cancer, C57BL/6 mouse) → Lung metastases.
- KPC model (pancreatic cancer, KRAS^G12D/p53^R172H, C57BL/6) → Liver, lung metastases.
Advanced Drug Administration & Serial Injections
We specialize in the following routes of administration:
Intravenous (IV), Intramuscular (IM), Subcutaneous (SC), Intrathecal (IT), Intra Peritoneal (IP), Oral Gavage (PO), Topical, Slow-infusion and Continuous Infusions – Ensuring accurate systemic or localized therapeutic exposure.
Serial Injections – Enabling longitudinal drug administration studies to monitor treatment effects over time.
Quality Control: Mycoplasma Testing
To ensure the highest standards in preclinical research, all cell lines used in our studies undergo rigorous mycoplasma testing, preventing contamination and ensuring reliable, reproducible results.
At MuriPhys, we are dedicated to accelerating oncology drug discovery with cutting-edge preclinical solutions. Contact us today to discuss how we can support your oncology research!
Partner with Us to Advance Your Oncology Research
By choosing our comprehensive services, you gain a trusted partner committed to de-risking your projects and accelerating your path to clinical success. Contact us today to discover how we can empower your oncology research and help bring innovative therapies to patients faster.
