Wilson's Disease Solutions
Understanding Wilson’s Disease
Wilson’s Disease is a rare genetic disorder characterized by excessive copper accumulation in the body, particularly in the liver and brain. This condition, caused by mutations in the ATP7B gene, leads to liver damage, neurological symptoms, and psychiatric disturbances. Without treatment, Wilson’s Disease can result in life-threatening organ damage and severe neurological impairment.
At Muriphys, we are dedicated to supporting preclinical research aimed at developing therapies to manage copper accumulation and mitigate organ damage, driving advancements in Wilson’s Disease treatment.
Precision Drug Delivery for Wilson’s Disease
Targeted drug delivery plays a crucial role in reducing systemic copper overload and preventing organ deterioration. Muriphys offers a variety of delivery methods tailored to Wilson’s Disease models, ensuring effective therapeutic distribution:
- Oral Gavage (OG) – Mimics human oral drug administration, allowing for repeated dosing and systemic distribution.
- Intravenous (IV) Injection – Facilitates rapid delivery of therapeutic agents directly into the bloodstream.
- Intraperitoneal (IP) Injection – Ensures systemic absorption, ideal for chelating agents targeting copper buildup.
- Subcutaneous (SC) Injection – Provides controlled, sustained release of therapeutics over time.
These diverse delivery methods support a wide range of therapeutic approaches, from gene therapies to chelation treatments, tailored to preclinical models of Wilson’s Disease.
Behavioral and Metabolic Assays
Wilson’s Disease not only affects the liver but also leads to neurological and motor dysfunction. Muriphys offers behavioral and metabolic assays designed to evaluate systemic effects and therapeutic efficacy:
- Rotarod and Balance Beam Tests – Assess motor coordination deficits resulting from copper-induced neurotoxicity.
- Open Field Test – Monitors general locomotion, anxiety, and exploratory behavior.
- Metabolic Chambers – Analyze systemic metabolic changes associated with liver dysfunction.
- Treadmill Testing – Evaluates endurance and muscular performance in models experiencing motor impairment.
These assays provide a comprehensive evaluation of disease progression, offering valuable insights into neurological and metabolic symptoms.
Imaging and Biomarker Analysis
Tracking disease progression and therapeutic response is vital in Wilson’s Disease research. Muriphys utilizes advanced imaging technologies and partners with third party CROs for biomarker assessment to monitor copper accumulation and liver health:
- Licor Pearl Imager – Enables in vivo imaging to assess liver function and detect pathological changes.
- Biochemical Analysis – Measures serum copper levels, ceruloplasmin, and liver enzymes to evaluate therapeutic impact.
- Histopathological Examination – Assesses liver fibrosis, cirrhosis, and neuronal damage.
These techniques provide critical data for understanding the effectiveness of therapeutic interventions in real-time.
Electrophysiology – Assessing Neurological Impact
Wilson’s Disease often results in neurological symptoms such as tremors, dystonia, and cognitive impairment. Muriphys employs EEG and EMG technologies to monitor neural activity and neuromuscular function, enabling precise evaluation of neurodegeneration and therapeutic response.
Electrophysiological services include:
- EEG Recording – Tracks brain activity to identify neurological impairments.
- EMG Analysis – Measures muscle function and motor abnormalities linked to copper toxicity.
These tools are essential for characterizing the neurological impact of Wilson’s Disease and evaluating the efficacy of interventions aimed at reversing neural damage.
Why Choose Muriphys for Wilson’s Disease Research?
Muriphys stands at the forefront of Wilson’s Disease research, offering tailored solutions that integrate precision drug delivery, comprehensive behavioral assays, and state-of-the-art imaging and electrophysiology. Our multidisciplinary approach empowers researchers to accelerate therapeutic development, transforming discoveries into effective treatments for Wilson’s Disease.
Reach out to us to learn more about how Muriphys can support your Wilson’s Disease research.
