Neurodevelopmental disorders shape the lives of millions, affecting cognitive, social, and motor functions from an early age. At MuriPhys, we are dedicated to providing innovative preclinical solutions that drive the development of therapies for these complex conditions. Our models mirror the genetic and environmental factors underlying neurodevelopmental disorders, offering precision drug delivery and comprehensive behavioral assessments.
MuriPhys partners with researchers to accelerate breakthroughs, shedding light on conditions such as autism, Fragile X syndrome, and Rett syndrome. Together, we shape the future of therapeutic intervention for those affected by developmental challenges.
Disorders We Specialize In:
Autism Spectrum Disorder (ASD)
Autism Spectrum Disorder is characterized by challenges in social interaction, communication, and repetitive behaviors. MuriPhys offers preclinical models utilizing intraparenchymal (IPa), intracerebroventricular (ICV), and intrathecal (IT) delivery to target key brain regions involved in ASD. Our behavioral assays assess social engagement, sensory processing, and motor coordination, while EEG studies provide biomarkers for neural dysfunction, guiding precision treatment development.
Fragile X research can combine CNS or systemic administration, including appropriate viral-vector or ICV work, with learning, attention and sensory assessments. Functional recordings are selected for the specific model and question.
Rett syndrome research can include IPa or IT delivery, motor and other model-appropriate behavioral assessments, EEG and EMG. EEG can characterize seizure-related activity. EMG assesses neuromuscular function, with the recording and analysis plan defined for the study. Rett Syndrome Read More.
Tourette Syndrome
Tourette Syndrome’s involuntary motor and vocal tics require specialized models that reflect its neurological basis. MuriPhys delivers therapeutics using IPa and ICV methods, targeting motor circuits and limbic pathways. Behavioral assays capture tic frequency and severity, while EEG recordings provide insights into the underlying neural activity, supporting robust evaluation of potential treatments.
Why MuriPhys for Neurodevelopmental Research?
- CNS Delivery: Select the administration route, target and study conditions for the developmental model and research question.
- Behavioral Testing: Select social, cognitive, sensory or motor tests for specific features of the neurodevelopmental model.
- Electrophysiology: EEG can characterize brain activity, including seizure-related findings where relevant. EMG adds neuromuscular measurements.
- Tailored Research Models: MuriPhys designs customized studies that reflect the unique developmental trajectories of each disorder, supporting translational relevance and impactful results.