Oncology Models
Oncology models play a critical role in preclinical development by enabling researchers to evaluate the efficacy, safety, and pharmacokinetics of investigational therapies in biologically relevant systems before entering clinical trials. These models—ranging from cell line-derived xenografts (CDX) and patient-derived xenografts (PDX) to orthotopic and metastatic tumor models—provide essential insights into tumor growth dynamics, therapeutic response, and resistance mechanisms.
At MuriPhys, we are uniquely positioned to support these studies with our specialized expertise in small animal handling, advanced in vivo imaging capabilities, and precision drug delivery techniques. Our ability to conduct serial tumor measurements, IV/IM/SC dosing, biodistribution studies, and histological analyses ensures a comprehensive and translational approach to oncology research, accelerating the path from discovery to clinical application.
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· Xenograft models – Human tumor cell lines implanted in immunodeficient mice.
· Patient-derived xenografts (PDX) – Tumors from patient biopsies implanted in mice for more clinical relevance.
· Syngeneic models – Murine tumor models in immunocompetent mice for immuno-oncology studies.
· Genetically engineered mouse models (GEMMs) – Tumor development driven by specific oncogenes.
· Metastasis models – Evaluating therapies targeting tumor spread
Advanced Drug Administration & Serial Injections
We specialize in the following routes of administration:
Intravenous (IV), Intramuscular (IM), Subcutaneous (SC), Intrathecal (IT), Intra Peritoneal (IP), Oral Gavage (PO), Topical, Slow-infusion and Continuous Infusions – Ensuring accurate systemic or localized therapeutic exposure.
Serial Injections – Enabling longitudinal drug administration studies to monitor treatment effects over time.
Quality Control: Mycoplasma Testing
To ensure the highest standards in preclinical research, all cell lines used in our studies undergo rigorous mycoplasma testing, preventing contamination and ensuring reliable, reproducible results.
At MuriPhys, we are dedicated to accelerating oncology drug discovery with cutting-edge preclinical solutions. Contact us today to discuss how we can support your oncology research!
Partner with Us to Advance Your Oncology Research
By choosing our comprehensive services, you gain a trusted partner committed to de-risking your projects and accelerating your path to clinical success. Contact us today to discover how we can empower your oncology research and help bring innovative therapies to patients faster.
